Anti-cancer effects of α-mangostin on human breast cancer cell lines (9783659799150)

In this book, α-mangostin (AM), a xanthone compound was investigated for its apoptosis mechanism on MCF-7 and MDA-MB-231 cell lines. The treatment of the cells with AM prompted apoptosis with cell death-transducing signals. This type of apoptosis was suggested to occur through the both extrinsic and intrinsic pathways and prevention of translocation of NF-κB from the cytoplasm to the nucleus. Our results revealed AM prompt apoptosis of the both cells through NF-κB, Bax/Bcl-2 and HSP70 protein modulation with the contribution of caspases. Therefore, AM is deemed to have considerable potential in the control of breast cancer.

Product details

• Format Paperback | 172 pages
• Dimensions 152 x 229 x 10mm | 259g
• Publication date 10 Nov 2015
• Publisher LAP Lambert Academic Publishing
• Language English
• Edition Statement Aufl.
• ISBN10 3659799157
• ISBN13 9783659799150

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